The structure and function of drug pumps

Borges-Walmsley, M.I. and Walmsley, A.R. (2001) The structure and function of drug pumps. Trends in Microbiology, 9, pp. 71-79.

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Abstract

Our understanding of the exact mechanisms used by the transmembrane protein pumps that confer cellular resistance to cytotoxic drugs has improved enormously with the recent determination of the structures of three Escherichia coli transporters, two belonging to the ATP-binding cassette (ABC) superfamily and one to the resistance-nodulation-cell division (RND) family. Although these studies do not provide an insight into how drug pumps can recognize several structurally unrelated drugs, important advances have been also made in this area. Information on the molecular basis of multidrug recognition has been provided by determining the structure of transcriptional regulators that can bind, often structurally unrelated, cytotoxic drugs and control the expression of drug pumps.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:UNSPECIFIED
Authors: Borges-Walmsley, M.I., and Walmsley, A.R.
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Trends in Microbiology

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