Estrogen metabolites in a small cohort of patients with idiopathic pulmonary arterial hypertension

Denver, N., Homer, N. Z.M., Andrew, R., Harvey, K. Y., Morrell, N., Austin, E. D. and Maclean, M. R. (2020) Estrogen metabolites in a small cohort of patients with idiopathic pulmonary arterial hypertension. Pulmonary Circulation, 10(1), pp. 1-5. (doi: 10.1177/2045894020908783)

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Abstract

Increased risk and severity of idiopathic pulmonary arterial hypertension (iPAH) is associated with elevated estradiol in men and postmenopausal women. Pulmonary arteries synthesise estradiol via aromatase and metabolise it via CYP1B1 to mitogenic metabolites; SNPs in aromatase and CYP1B1 have been associated with PAH. This suggests that estradiol metabolism could be altered in iPAH. This proof-of-concept study profiles estradiol and several metabolites of estradiol simultaneously in serum from iPAH patients and controls. We show that the estradiol and metabolite profile is altered in iPAH and that 16-hydroxyestrone and 16-hydroxyestradiol accumulate in iPAH patients with 16-hydroxyestrone levels relating to disease severity.

Item Type:Articles
Additional Information:The project described was supported by the British Heart Foundation, through grants RE/13/5/30177 and RG/16/2/32153, the Wellcome Trust (108468/z/15/z), the National Institutes of Health (R01HL134802 and P01HL108800), and a BBSRC iCASE PhD award (BB/N503691/1).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Harvey, Dr Katie and Maclean, Miss Margaret and Denver, Nina
Authors: Denver, N., Homer, N. Z.M., Andrew, R., Harvey, K. Y., Morrell, N., Austin, E. D., and Maclean, M. R.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Pulmonary Circulation
Publisher:SAGE Publications
ISSN:2045-8932
ISSN (Online):2045-8940
Published Online:13 February 2020
Copyright Holders:Copyright © The Author(s) 2020
First Published:First published in Pulmonary Circulation 10(1):1-5
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190814BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177Institute of Cardiovascular & Medical Sciences
173026Sex and the development of pulmonary arterial hypertensionMargaret MacLeanBritish Heart Foundation (BHF)RG/16/2/32153Institute of Cardiovascular & Medical Sciences