Denver, N., Homer, N. Z.M., Andrew, R., Harvey, K. Y., Morrell, N., Austin, E. D. and Maclean, M. R. (2020) Estrogen metabolites in a small cohort of patients with idiopathic pulmonary arterial hypertension. Pulmonary Circulation, 10(1), pp. 1-5. (doi: 10.1177/2045894020908783)
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Abstract
Increased risk and severity of idiopathic pulmonary arterial hypertension (iPAH) is associated with elevated estradiol in men and postmenopausal women. Pulmonary arteries synthesise estradiol via aromatase and metabolise it via CYP1B1 to mitogenic metabolites; SNPs in aromatase and CYP1B1 have been associated with PAH. This suggests that estradiol metabolism could be altered in iPAH. This proof-of-concept study profiles estradiol and several metabolites of estradiol simultaneously in serum from iPAH patients and controls. We show that the estradiol and metabolite profile is altered in iPAH and that 16-hydroxyestrone and 16-hydroxyestradiol accumulate in iPAH patients with 16-hydroxyestrone levels relating to disease severity.
Item Type: | Articles |
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Additional Information: | The project described was supported by the British Heart Foundation, through grants RE/13/5/30177 and RG/16/2/32153, the Wellcome Trust (108468/z/15/z), the National Institutes of Health (R01HL134802 and P01HL108800), and a BBSRC iCASE PhD award (BB/N503691/1). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Harvey, Dr Katie and Maclean, Miss Margaret and Denver, Nina |
Authors: | Denver, N., Homer, N. Z.M., Andrew, R., Harvey, K. Y., Morrell, N., Austin, E. D., and Maclean, M. R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Pulmonary Circulation |
Publisher: | SAGE Publications |
ISSN: | 2045-8932 |
ISSN (Online): | 2045-8940 |
Published Online: | 13 February 2020 |
Copyright Holders: | Copyright © The Author(s) 2020 |
First Published: | First published in Pulmonary Circulation 10(1):1-5 |
Publisher Policy: | Reproduced under a Creative Commons license |
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