Elevated pulse pressure during the acute period of ischemic stroke is associated with poor stroke outcome

Aslanyan, S., Weir, C.J. and Lees, K.R. (2004) Elevated pulse pressure during the acute period of ischemic stroke is associated with poor stroke outcome. Stroke, 35(6), e153-e155. (doi: 10.1161/01.STR.0000126598.88662.16)

Abstract

<p><b>Background:</b> It is controversial which component of blood pressure (BP) during acute period of stroke best predicts outcome. We hypothesized that elevated pulse pressure (PP), the difference between systolic BP (SBP) and diastolic BP (DBP), is independently associated with poor stroke outcome at 3 months.</p> <p><b>Methods:</b> We analyzed both treatment groups from the Glycine Antagonist (Gavestinel) in Neuroprotection (GAIN) International trial (1455 ischemic stroke cases of mostly moderate severity). Cox proportional hazards and logistic regression modeling corrected for demography, medical history, heart rate, stroke severity, and clinical subtype.</p> <p><b>Results:</b> Elevated weighted average PP during the first 60 hours was associated with poor outcome by mortality, Barthel index, National Institutes of Health Stroke Score (NIHSS) and Rankin scores. Elevated baseline PP was associated with Barthel index and Rankin score.</p> <p><b>Conclusion:</b> Elevated PP is associated with poor stroke outcome at 3 months.</p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lees, Professor Kennedy
• Authors: Aslanyan, S., Weir, C.J., and Lees, K.R.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Stroke
• Publisher: American Heart Association
• ISSN: 0039-2499
• Copyright Holders: Copyright © 2004 American Heart Association
• First Published: First published in Stroke 35(6):e153-e155
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher