Beard, D. A., Hoitzing, H., Gammage, P. A. , Haute, L. V., Minczuk, M., Johnston, I. G. and Jones, N. S. (2019) Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations. PLoS Computational Biology, 15(6), e1007023. (doi: 10.1371/journal.pcbi.1007023) (PMID:31242175) (PMCID:PMC6615642)
|
Text
211574.pdf - Published Version Available under License Creative Commons Attribution. 3MB |
Abstract
The dynamics of the cellular proportion of mutant mtDNA molecules is crucial for mitochondrial diseases. Cellular populations of mitochondria are under homeostatic control, but the details of the control mechanisms involved remain elusive. Here, we use stochastic modelling to derive general results for the impact of cellular control on mtDNA populations, the cost to the cell of different mtDNA states, and the optimisation of therapeutic control of mtDNA populations. This formalism yields a wealth of biological results, including that an increasing mtDNA variance can increase the energetic cost of maintaining a tissue, that intermediate levels of heteroplasmy can be more detrimental than homoplasmy even for a dysfunctional mutant, that heteroplasmy distribution (not mean alone) is crucial for the success of gene therapies, and that long-term rather than short intense gene therapies are more likely to beneficially impact mtDNA populations.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Gammage, Dr Payam |
Creator Roles: | |
Authors: | Beard, D. A., Hoitzing, H., Gammage, P. A., Haute, L. V., Minczuk, M., Johnston, I. G., and Jones, N. S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | PLoS Computational Biology |
Publisher: | Public Library of Science |
ISSN: | 1553-734X |
ISSN (Online): | 1553-7358 |
Copyright Holders: | Copyright © 2019 Hoitzing et al. |
First Published: | First published in PLoS Computational Biology 15(6):e1007023 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record