Selective-cold output through a distinct subset of lamina I spinoparabrachial neurons

Hachisuka, J. , Koerber, H. R. and Ross, S. E. (2020) Selective-cold output through a distinct subset of lamina I spinoparabrachial neurons. Pain, 161(1), pp. 185-194. (doi: 10.1097/j.pain.0000000000001710) (PMID:31577643)

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Abstract

Spinal projection neurons are a major pathway through which somatic stimuli are conveyed to the brain. However, the manner in which this information is coded is poorly understood. Here, we report the identification of a modality-selective spinoparabrachial (SPB) neuron subtype with unique properties. Specifically, we find that cold-selective SPB neurons are differentiated by selective afferent input, reduced sensitivity to substance P, distinct physiological properties, small soma size, and low basal drive. In addition, optogenetic experiments reveal that cold-selective SPB neurons do not receive input from Nos1 inhibitory interneurons and, compared with other SPB neurons, show significantly smaller inhibitory postsynaptic currents upon activation of Pdyn inhibitory interneurons. Together, these data suggest that cold output from the spinal cord to the parabrachial nucleus is mediated by a specific cell type with distinct properties.

Item Type:Articles
Additional Information:Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number R01AR063772 to S.E. Ross and the National Institute of Neurological Disorder and Stroke of the National Institutes of Health under Award Number R01 NS096705 to H.R. Koerber.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hachisuka, Dr Junichi
Authors: Hachisuka, J., Koerber, H. R., and Ross, S. E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Pain
Publisher:Lippincott, Williams and Wilkins
ISSN:0304-3959
ISSN (Online):1872-6623
Published Online:01 October 2019
Copyright Holders:Copyright © 2019 International Association for the Study of Pain
First Published:First published in Pain 161(1):185-194
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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