Singhal, A., Jamieson, N.B., Fewtrell, M., Deanfield, J., Lucas, A. and Sattar, N. (2005) Adiponectin predicts insulin resistance but not endothelial function in young, healthy adolescents. Journal of Clinical Endocrinology and Metabolism, 90(8), pp. 4615-4621. (doi: 10.1210/jc.2005-0131)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1210/jc.2005-0131
Abstract
<p><b>Background:</b> Adiponectin, an adipocyte-derived hormone found in lower concentration with greater adiposity, is suggested to reduce the risk of insulin resistance, atherosclerosis, and cardiovascular disease. We tested this hypothesis in a healthy, nonobese population.</p> <p><b>Methods and Results:</b> Brachial artery flow-mediated endothelial-dependent vasodilation and distensibility, measures of vascular function relevant to the early atherosclerotic process, were determined in 294 adolescents (aged 13–16 yr) using high-resolution vascular ultrasound. Fasting insulin concentration and the homeostasis model assessment of insulin resistance were used to estimate insulin resistance. Fat mass was measured by bioelectric impedance analysis; fasting serum adiponectin concentration by RIA; and lipid profile, fasting insulin, glucose, and C-reactive protein concentrations using standard laboratory techniques. Adiponectin concentration was associated with insulin resistance independent of potential confounding factors (e.g. −1.3% change in fasting insulin concentration per 10% increase in adiponectin concentration; 95% confidence interval, −2.4% to −0.1%; P = 0.03), but not with flow-mediated endothelial-dependent vasodilation or arterial distensibility.</p> <p><b>Conclusions:</b> Lower adiponectin concentration was associated with lower insulin sensitivity in a healthy, nonobese population. Our study supports the hypothesis that adiponectin benefits insulin sensitivity from a young age but, in contrast to experimental models and data from older subjects, does not affect vascular changes associated with early atherosclerosis.</p>
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Jamieson, Professor Nigel and Sattar, Professor Naveed |
Authors: | Singhal, A., Jamieson, N.B., Fewtrell, M., Deanfield, J., Lucas, A., and Sattar, N. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Journal of Clinical Endocrinology and Metabolism |
ISSN: | 0021-972X |
ISSN (Online): | 1945-7197 |
University Staff: Request a correction | Enlighten Editors: Update this record