Cytokines at the interplay between asthma and atherosclerosis?

Gurgone, D., McShane, L. , McSharry, C., Guzik, T. J. and Maffia, P. (2020) Cytokines at the interplay between asthma and atherosclerosis? Frontiers in Pharmacology, 11, 166. (doi: 10.3389/fphar.2020.00166)

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Cardiovascular disease (CVD) is an important comorbidity in a number of chronic inflammatory diseases. However, evidence in highly prevalent respiratory disease such as asthma are still limited. Epidemiological and clinical data are not univocal in supporting the hypothesis that asthma and CVD are linked and the mechanisms of this relationship remain poorly defined. In this review, we explore the relationship between asthma and cardiovascular disease, with a specific focus on cytokine contribution to vascular dysfunction and atherosclerosis. This is important in the context of recent evidence linking broad inflammatory signalling to cardiovascular events. However inflammatory regulation in asthma is different to the one typically observed in atherosclerosis. We focus on the contribution of cytokine networks encompassing IL-4, IL-6, IL-9, IL-17A, IL-33 but also IFN-γ and TNF-α to vascular dysfunction in atherosclerosis. In doing so we highlight areas of unmet need and possible therapeutic implications.

Item Type:Articles
Additional Information:Our work is supported by the British Heart Foundation (BHF) grants PG/12/81/29897, RE/13/5/30177, FS/16/55/32731, and PG/19/84/34771; the Engineering and Physical Sciences Research Council (EPSRC) grant EP/L014165/1; the European Commission Marie Skłodowska-Curie Individual Fellowships 661369 and the European Research Council (Project Identifier: 726318).
Glasgow Author(s) Enlighten ID:McShane, Ms Lucy and Maffia, Professor Pasquale and Gurgone, Dr Danila and Guzik, Professor Tomasz and McSharry, Dr Charles
Creator Roles:
Gurgone, D.Writing – original draft
McShane, L.Writing – original draft
McSharry, C.Writing – review and editing
Guzik, T.Writing – review and editing
Maffia, P.Writing – review and editing
Authors: Gurgone, D., McShane, L., McSharry, C., Guzik, T. J., and Maffia, P.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Research Centre:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
Journal Name:Frontiers in Pharmacology
Publisher:Frontiers Media
ISSN (Online):1663-9812
Copyright Holders:Copyright © 2020 Gurgone, McShane, McSharry, Guzik and Maffia
First Published:First published in Frontiers in Pharmacology 11:166
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190580Defining innate and adaptive immune functions of plasmacytoid dendritic cells in atherosclerosis.Pasquale MaffiaBritish Heart Foundation (BHF)PG/12/81/29897III - Immunology
190814BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177Institute of Cardiovascular & Medical Sciences
173470BHF 4-Year PhD Studentship (4th intake 2016 of 3rd Scheme)Rhian TouyzBritish Heart Foundation (BHF)FS/16/55/32731Institute of Cardiovascular & Medical Sciences
308639Defining the individual and integrated roles of inflammatory chemokine receptors (iCCRs) in atherosclerosisPasquale MaffiaBritish Heart Foundation (BHF)PG/19/84/34771CAMS - Cardiovascular Science
190739In Situ Nanoparticle Assemblies for Healthcare Diagnostics and Therapy. Reference: 130479Pasquale MaffiaEngineering and Physical Sciences Research Council (EPSRC)EP/L014165/1III - Immunology
171799NanoMATePasquale MaffiaEuropean Commission (EC)661369III - Immunology
300798A study of the roles of the immune and inflammatory systems in hypertensionTomasz GuzikEuropean Research Council (ERC)726318CAMS - Cardiovascular Science