Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes

Ran, T. et al. (2020) Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes. Lab on a Chip, 20, pp. 1002-1011. (doi: 10.1039/C9LC01189G) (PMID:32026889)

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Integration of microfluidics and biosensing functionalities on a single device holds promise in continuous health monitoring and disease diagnosis for point-of-care applications. However, the required functions of fluid handling and biomolecular sensing usually arise from different actuation mechanisms. In this work, we demonstrate that a single acoustofluidic device, based on a flexible thin film platform, is able to generate hybrid wave modes, which can be used for fluidic actuation (Lamb waves) and biosensing (thickness shear waves). On this integrated platform, we show multiple and sequential functions of mixing, transport and disposal of liquid volumes using Lamb waves, whilst the thickness bulk shear waves allow us to sense the chemotherapeutic Imatinib, using an aptamer-based strategy, as would be required for therapy monitoring. Upon binding, the conformation of the aptamer results in a change in coupled mass, which has been detected. This platform architecture has the potential to generate a wide range of simple sample-to-answer biosensing acoustofluidic devices.

Item Type:Articles
Additional Information:This work was financially supported by Research and Development Program of China (Grant no. 2016YFB0402705), the UK Engineering and Physical Sciences Research Council (EPSRC) grants EP/L026899/1, EP/P018998/1 and EP/K027611/1, Shenzhen Key Lab Fund (ZDSYS20170228105421966), Shenzhen Science & Technology Project (Grant no. JCYJ20170817100658231). The work is also supported by Special Interests Group of Acoustofluidics under the EPSRC-funded UK Fluidic Network (EP/N032861/1).
Glasgow Author(s) Enlighten ID:Reboud, Dr Julien
Authors: Ran, T., Reboud, J., Torun, H., McHale, G., Dodd, L. E., Wu, Q., Tao, K., Yang, X., Luo, J. T., Todryk, S., and Fu, Y.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Lab on a Chip
Publisher:Royal Society of Chemistry
ISSN (Online):1473-0189
Copyright Holders:Copyright © 2020 The Royal Society of Chemistry
First Published:First published in Lab on a Chip 20:1002-1011
Publisher Policy:Published under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
168637Advanced Diagnostics using PhononicsJonathan CooperEngineering and Physical Sciences Research Council (EPSRC)EP/K027611/1ENG - Biomedical Engineering