Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver

Ayala, V., Naudi, A., Sanz Montero, A., Caro, P., Portero-Otin, M., Barja, G. and Pamplona, R. (2007) Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 62(4), pp. 352-360. (doi:10.1093/gerona/62.4.352)

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Abstract

Caloric restriction (CR) decreases oxidative damage, which contributes to the slowing of aging rate. It is not known if such decreases are due to calories themselves or specific dietary components. In this work, the ingestion of proteins of Wistar rats was decreased by 40% below that of controls. After 7 weeks, the liver of the protein-restricted (PR) animals showed decreases in oxidative protein damage, degree of membrane unsaturation, and mitochondrial complex I content. The results and previous information suggest that the decrease in the rate of aging induced by PR can be due in part to decreases in mitochondrial reactive oxygen species production and DNA and protein oxidative modification, increases in fatty acid components more resistant to oxidative damage, and decreased expression of complex I, analogously to what occurs during CR. Recent studies suggest that those benefits of PR could be caused, in turn, by the lowered methionine intake of that dietary manipulation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sanz Montero, Professor Alberto
Authors: Ayala, V., Naudi, A., Sanz Montero, A., Caro, P., Portero-Otin, M., Barja, G., and Pamplona, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher:Oxford University Press
ISSN:1079-5006

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