Target of rapamycin activation predicts lifespan in fruit flies

Scialò, F., Sriram, A., Naudí, A., Ayala, V., Jové, M., Pamplona, R. and Sanz, A. (2015) Target of rapamycin activation predicts lifespan in fruit flies. Cell Cycle, 14(18), pp. 2949-2958. (doi:10.1080/15384101.2015.1071745) (PMID:26259964) (PMCID:PMC4630862)

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Abstract

Aging and age-related diseases are one of the most important health issues that the world will confront during the 21st century. Only by understanding the proximal causes will we be able to find treatments to reduce or delay the onset of degenerative diseases associated with aging. Currently, the prevalent paradigm in the field is the accumulation of damage. However, a new theory that proposes an alternative explanation is gaining momentum. The hyperfunction theory proposes that aging is not a consequence of a wear and tear process, but a result of the continuation of developmental programs during adulthood. Here we use Drosophila melanogaster, where evidence supporting both paradigms has been reported, to identify which parameters that have been previously related with lifespan best predict the rate of aging in wild type flies cultured at different temperatures. We find that mitochondrial function and mitochondrial reactive oxygen species (mtROS) generation correlates with metabolic rate, but not with the rate of aging. Importantly, we find that activation of nutrient sensing pathways (i.e. insulin-PI3K/Target of rapamycin (Tor) pathway) correlates with lifespan, but not with metabolic rate. Our results, dissociate metabolic rate and lifespan in wild type flies and instead link nutrient sensing signaling with longevity as predicted by the hyperfunction theory.

Item Type:Articles
Additional Information:This study was supported by the European Research Council (ERC Starting Grant to A.S.), the Academy of Finland (Research Academy Fellowship to A.S), the Spanish Ministry of Economy and Competitiveness (BFU2009-11879/BFI; RD12/0043/0018 and PI1400328 to R.P.), and the Autonomous Government of Catalonia (2014SGR168 to R.P).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sanz Montero, Professor Alberto
Authors: Scialò, F., Sriram, A., Naudí, A., Ayala, V., Jové, M., Pamplona, R., and Sanz, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Cell Cycle
Publisher:Taylor & Francis
ISSN:1538-4101
ISSN (Online):1551-4005
Published Online:22 September 2015
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Cell Cycle 14(18):2949-2958
Publisher Policy:Reproduced under a Creative Commons License

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