O'Boyle, N., Turner, N. C.A., Roe, A. J. and Connolly, J. P.R. (2020) Plastic circuits: regulatory flexibility in fine tuning pathogen success. Trends in Microbiology, 28(5), pp. 360-371. (doi: 10.1016/j.tim.2020.01.002) (PMID:32298614)
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Abstract
Bacterial pathogens employ diverse fitness and virulence mechanisms to gain an advantage in competitive niches. These lifestyle-specific traits require integration into the regulatory network of the cell and are often controlled by pre-existing transcription factors. In this review, we highlight recent advances that have been made in characterizing this regulatory flexibility in prominent members of the Enterobacteriaceae. We focus on the direct global interactions between transcription factors and their target genes in pathogenic Escherichia coli and Salmonella revealed using chromatin immunoprecipitation coupled with next-generation sequencing. Furthermore, the implications and advantages of such regulatory adaptations in benefiting distinct pathogenic lifestyles are discussed.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Turner, Natasha and Connolly, Dr James and Roe, Professor Andrew and O Boyle, Dr Nicky |
Authors: | O'Boyle, N., Turner, N. C.A., Roe, A. J., and Connolly, J. P.R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Trends in Microbiology |
Publisher: | Elsevier (Cell Press) |
ISSN: | 0966-842X |
ISSN (Online): | 1878-4380 |
Published Online: | 12 February 2020 |
Copyright Holders: | Copyright © 2020 The Authors |
First Published: | First published in Trends in Microbiology 28(5): 360-371 |
Publisher Policy: | Reproduced under a Creative Commons License |
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