Human granulocyte-macrophage colony-stimulating factor: the protein and its current & emerging applications

Ghosh, P. K., Bhardwaj, D. and Karnik, R. (2007) Human granulocyte-macrophage colony-stimulating factor: the protein and its current & emerging applications. Indian Journal of Biotechnology, 6(4), pp. 435-448.

Abstract

Blood cells under a variety of conditions produce cytokines which regulate their proliferation, communication and functioning. The granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor mainly responsible for the proliferation of granulocyte-s and macrophages. It is a molecule of immense therapeutic interest due to its wide-ranging actions on immune cells. Recombinant human GM-CSF has been expressed, purified and characterized. It has diverse biological manifestations, which has led to its being explored for use in cancer therapy, AIDS therapy, as a vaccine adjuvant, in certain types of wound healing, promotion of collateral growth of coronary artery, usefulness in treating Crohn’s disease symptoms and in the management of a host of viral, bacterial and fungal infections. Newer therapeutic applications are also being unveiled. The physico-chemical as well as the biological features and the applications (current and emerging) of GM-CSF are discussed.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Karnik, Dr Rucha
• Authors: Ghosh, P. K., Bhardwaj, D., and Karnik, R.
• College/School: College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Indian Journal of Biotechnology
• Publisher: National Institute of Science Communication and Information Resources
• ISSN: 0972-5849