A theoretical analysis of the role of pyrophosphate,fructose 6-P,1-phosphotransferase in energy dissipation during the conversion of fructose 6-phosphate to fructose 1,6-bisphosphate in plant cells

Liu, J., Crawford, J. W. and Viola, R. (1997) A theoretical analysis of the role of pyrophosphate,fructose 6-P,1-phosphotransferase in energy dissipation during the conversion of fructose 6-phosphate to fructose 1,6-bisphosphate in plant cells. Journal of Biological Systems, 05(03), pp. 389-401. (doi: 10.1142/S0218339097000242)

Abstract

A theoretical analysis of the effect of pyrophosphate,fructose 6-P,1-phosphotransferase (PFP) on energy dissipation in the conversion of fructose 6-phosphate to fructose 1,6-bisphosphate is presented. The conclusion depends sensitively on whether PFP is in equilibrium, or catalyses a net flux in the directions of gluconeogenesis or glycolysis. It is shown that the conditions under which PFP is in equilibrium are rather restricted. Furthermore, experimental evidence supports the theoretical prediction that PFP catalyses a net flux in real systems. When PFP catalyses a net glycolytic flux, the system where both PFP and PFK are active always dissipates less energy than the system where only PFK exists. However, when PFP catalyses a net flux in gluconeogenesis, the PFK-PFP system dissipates more energy than the system where only PFK exists. By comparing the theoretical work with experimental results, the evidence suggests that PFP in higher plant cells catalyses a net glycolytic flux, and its presence increases the energetic efficiency of glycolysis.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Crawford, Professor John
• Authors: Liu, J., Crawford, J. W., and Viola, R.
• College/School: College of Social Sciences > Adam Smith Business School > Management
• Journal Name: Journal of Biological Systems
• Publisher: World Scientific Publishing
• ISSN: 0218-3390
• ISSN (Online): 1793-6470