The emerging role of GABAB receptors as regulators of network dynamics: fast actions from a 'slow' receptor?

Craig, M. T. and McBain, C. J. (2014) The emerging role of GABAB receptors as regulators of network dynamics: fast actions from a 'slow' receptor? Current Opinion in Neurobiology, 26, pp. 15-21. (doi: 10.1016/j.conb.2013.10.002) (PMID:24650499) (PMCID:PMC4024344)

Abstract

Convention holds that ionotropic receptors mediate fast neurotransmission and that ‘slow’ G-protein coupled metabotropic receptors have a secondary, modulatory role in the control of neuronal networks. Here, we discuss recent evidence showing that activation of metabotropic GABAB receptors in cortical layer 1 can powerfully inhibit principal cell activity and that their activation can rapidly halt ongoing network activity. Inputs from both within and outwith the cortex converge upon layer 1 where they target various populations of interneurons, including neurogliaform cells. We argue that neurogliaform cells are the main effector of a powerful inhibitory circuit that, acting through GABAB receptors, can be differentially recruited by long-range connections to serve in roles as diverse as conscious perception and memory consolidation.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Craig, Dr Mick
• Authors: Craig, M. T., and McBain, C. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Current Opinion in Neurobiology
• Publisher: Elsevier
• ISSN: 0959-4388
• ISSN (Online): 1873-6882
• Published Online: 19 November 2013