Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike-times in the neocortex

Jang, H. J., Chung, H., Rowland, J. M., Richards, B. A., Kohl, M. M. and Kwag, J. (2020) Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike-times in the neocortex. Science Advances, 6(17), eaay5333. (doi: 10.1126/sciadv.aay5333) (PMID:32426459) (PMCID:PMC7176419)

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Abstract

Synchronization of precise spike times across multiple neurons carries information about sensory stimuli. Inhibitory interneurons are suggested to promote this synchronization, but it is unclear whether distinct interneuron subtypes provide different contributions. To test this, we examined single-unit recordings from barrel cortex in vivo and used optogenetics to determine the contribution of parvalbumin (PV)– and somatostatin (SST)–positive interneurons to the synchronization of spike times across cortical layers. We found that PV interneurons preferentially promote the synchronization of spike times when instantaneous firing rates are low (<12 Hz), whereas SST interneurons preferentially promote the synchronization of spike times when instantaneous firing rates are high (>12 Hz). Furthermore, using a computational model, we demonstrate that these effects can be explained by PV and SST interneurons having preferential contributions to feedforward and feedback inhibition, respectively. Our findings demonstrate that distinct subtypes of inhibitory interneurons have frequency-selective roles in the spatiotemporal synchronization of precise spike times.

Item Type:Articles
Additional Information:This work was supported by the Human Frontiers Science Program (HFSP) Young Investigator Award (RGY0073/2015) to B.A.R., M.M.K., and J.K. and by the National Research Foundation of Korea (NRF-2019M3E5D2A01058328) to J.K. H.J.J. was supported by a Korea University grant. J.M.R. was supported by a Wellcome Trust Prize Studentship.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kohl, Dr Michael
Authors: Jang, H. J., Chung, H., Rowland, J. M., Richards, B. A., Kohl, M. M., and Kwag, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Science Advances
Publisher:American Association for the Advancement of Science
ISSN:2375-2548
ISSN (Online):2375-2548
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Science Advances 6(17):eaay5333
Publisher Policy:Reproduced under a Creative Commons License

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