Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence

Bell, J. D., Harkiss, A. H., Nobis, D., Malcolm, E., Knuhtsen, A., Wellaway, C. R., Jamieson, A. G. , Magennis, S. W. and Sutherland, A. (2020) Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence. Chemical Communications, 56(12), pp. 1887-1890. (doi: 10.1039/C9CC09064A) (PMID:31956866)

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Abstract

The synthesis and photophysical properties of a new class of α-amino acid bearing a rigid pyrazoloquinazoline chromophore are described. Confromational constraint of the amino acid side-chains resulted in high emission quantum yields, while the demonstration of two-photon-induced fluorescence via near-IR excitation signifies their potential for sensitive bioimaging applications.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Magennis, Dr Steven and Knuhtsen, Dr Astrid and Harkiss, Mr Alexander and Bell, Mr Jonathan and Jamieson, Dr Andrew and Sutherland, Dr Andrew and Nobis, Mr David
Authors: Bell, J. D., Harkiss, A. H., Nobis, D., Malcolm, E., Knuhtsen, A., Wellaway, C. R., Jamieson, A. G., Magennis, S. W., and Sutherland, A.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:13 January 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Chemical Communications 56(12):1887-1890
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172233Anderson ICASE 2015 (Selex)Heather LambieEngineering and Physical Sciences Research Council (EPSRC)IND CASE EP/N509176/1S&E - Academic & Student Administration
190490Engineering and Physical Sciences Doctoral Training Grant 2012-16Mary Beth KneafseyEngineering and Physical Sciences Research Council (EPSRC)EP/K503058/1Research and Innovation Services