Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery

Yan, L., Chen, W., Zhu, X., Huang, L., Wang, Z., Zhu, G., Roy, V.A.L. , Yu, K.N. and Chen, X. (2013) Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery. Chemical Communications, 49(93), pp. 10938-10940. (doi: 10.1039/c3cc45714a) (PMID:24129414)

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Abstract

Enhanced selectivity and efficacy is important for advanced drug delivery. Herein, a novel type of folic acid conjugated self-assembled layered double hydroxide nanoparticles is reported. These nanoparticles have a drug loading capacity of 27 wt% and are able to enter cell nuclei and dramatically improve the efficacy of MTX.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vellaisamy, Professor Roy
Authors: Yan, L., Chen, W., Zhu, X., Huang, L., Wang, Z., Zhu, G., Roy, V.A.L., Yu, K.N., and Chen, X.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:02 October 2013

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