Size controllable and surface tunable zeolitic imidazolate framework-8–poly(acrylic acid sodium salt) nanocomposites for pH responsive drug release and enhanced in vivo cancer treatment

Yan, L. et al. (2017) Size controllable and surface tunable zeolitic imidazolate framework-8–poly(acrylic acid sodium salt) nanocomposites for pH responsive drug release and enhanced in vivo cancer treatment. ACS Applied Materials and Interfaces, 9(38), pp. 32990-33000. (doi: 10.1021/acsami.7b10064) (PMID:28876048)

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Abstract

Nanoscale size controllable and surface modifiable zeolitic imidazolate framework-8–poly(acrylic acid sodium salt) (ZIF-8–PAAS) nanocomposites are fabricated by employing PAAS nanospheres as a soft template. These ZIF-8–PAAS nanocomposites have different sizes ranging from 30 to 200 nm and exhibit different crystallinity, and pH sensitivity. These nanocomposites can be employed as vectors to deliver doxorubicin for anticancer therapy, leading to greatly enhanced drug therapeutic efficacy when tested in cell lines and mice model. Systematic toxicity investigation including hematoxylin and eosin staining analysis of tumor and major organs, hematology analysis, and blood chemistry analysis indicates that the nanocomposites possess high biocompatibility. This work provides a strategy to make metal–organic frameworks (MOFs) nanocomposites with size tunability in nanoscale and flexible surface modification for various applications.

Item Type:Articles
Additional Information:The work was financially supported by the General Research Fund of Hong Kong (CityU Grant Nos. 11338516 and 11306717), the School of Engineering of University of Edinburgh, the Royal Society Research Grant Scheme RG150564, and the Chengdu University (Grant Nos. 2081916010 and ARRLKF16-05).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vellaisamy, Professor Roy
Authors: Yan, L., Chen, X., Wang, Z., Zhang, X., Zhu, X., Zhou, M., Chen, W., Huang, L., Roy, V. A.L., Yu, P. K.N., Zhu, G., and Zhang, W.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:ACS Applied Materials and Interfaces
Publisher:American Chemical Society
ISSN:1944-8244
ISSN (Online):1944-8252
Published Online:18 September 2017

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