Reconfigurable Particle Separation by Dynamic Acoustic Fields in Microfluidic Devices

Simon, G. et al. (2017) Reconfigurable Particle Separation by Dynamic Acoustic Fields in Microfluidic Devices. In: 24th International Conference on Sound and Vibration, London, UK, 23-27 Jul 2017,

Abstract

Advances in diagnostics, cell and stem cell technologies drive the development of application specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for label-free, high recovery, cell and particle separation and isolation in tissue engineering and targeted drug delivery. In this paper, we present two methods of separating particles in a microfluidic channel. The first method uses custom-made micro-particles and by changing the acoustic contrast factor, the micro-particles shift from acoustic node to antinodes, compared to commercialised micro-particles. The second method relies on shifting the acoustic standing wave in a pattern called dynamic acoustic field. We demonstrate that both methods separate particles up to 100%.

• Item Type: Conference Proceedings
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Roolvink, Danny and Bernassau, Dr Anne and Riehle, Dr Mathis and Cooper, Professor Jonathan and Reboud, Dr Julien
• Authors: Simon, G., Marques-Hues, J., Desmulliez, M. P.Y., Bernassau, A. L., Roolvink, D., Burns, G., Cormack, P.A.G., Andrade, M. A.B., Reboud, J., Cooper, J. M., and Riehle, M. O.
• College/School: College of Medical Veterinary and Life Sciences > School of Molecular Biosciences; College of Science and Engineering > School of Engineering > Biomedical Engineering; College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering