Disposable paper-on-CMOS platform for real-time simultaneous detection of metabolites

Hu, C. , Annese, V. , Velugotla, S. , Al-Rawhani, M. A., Cheah, B. C. , Grant, J. , Barrett, M. P. and Cumming, D. R.S. (2020) Disposable paper-on-CMOS platform for real-time simultaneous detection of metabolites. IEEE Transactions on Biomedical Engineering, 67(9), pp. 2417-2426. (doi: 10.1109/TBME.2019.2962239)

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Objective: Early stage diagnosis of sepsis without overburdening health services is essential to improving patient outcomes. Methods: A fast and simple-to-use platform that combines an integrated circuit with paper microfluidics for simultaneous detection of multiple-metabolites appropriate for diagnostics was presented. Paper based sensors are a primary candidate for widespread deployment of diagnostic or test devices. However, the majority of devices today use a simple paper strip to detect a single marker using the reflectance of light. However, for many diseases such as sepsis, one biomarker is not sufficient to make a unique diagnosis. In this work multiple measurements are made on patterned paper simultaneously. Using laser ablation to fabricate microfluidic channels on paper provides a flexible and direct approach for mass manufacture of disposable paper strips. A reusable photodiode array on a complementary metal oxide semiconductor chip is used as the transducer. Results: The system measures changes in optical absorbance in the paper to achieve a cost-effective and easily implemented system that is capable of multiple simultaneous assays. Potential sepsis metabolite biomarkers glucose and lactate have been studied and quantified with the platform, achieving sensitivity within the physiological range in human serum. Conclusion: We have detailed a disposable paper-based CMOS photodiode sensor platform for real-time simultaneous detection of metabolites for diseases such as sepsis. Significance: A combination of a low-cost paper strip with microfluidic channels and a sensitive CMOS photodiode sensor array makes our platform a robust portable and inexpensive biosensing device for multiple diagnostic tests in many different applications.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Al-Rawhani, Dr Mohammed and Velugotla, Dr Srinivas and Cumming, Professor David and Cheah, Dr Boon Chong and Grant, Dr James and Hu, Dr Chunxiao and Annese, Dr Valerio and Barrett, Professor Michael
Authors: Hu, C., Annese, V., Velugotla, S., Al-Rawhani, M. A., Cheah, B. C., Grant, J., Barrett, M. P., and Cumming, D. R.S.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:IEEE Transactions on Biomedical Engineering
ISSN (Online):1558-2531
Published Online:30 January 2020
Copyright Holders:Copyright © 2020 IEEE
First Published:First published in IEEE Transactions on Biomedical Engineering 67(9): 2417-2426
Publisher Policy:Reproduced under a Creative Commons License
Data DOI:10.5525/gla.researchdata.817

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190623The Multi-Corder: Poly-Sensor TechnologyDavid CummingEngineering and Physical Sciences Research Council (EPSRC)EP/K021966/1ENG - Electronics & Nanoscale Engineering