The drugs of sleeping sickness: their mechanisms of action and resistance, and a brief history

De Koning, H. P. (2020) The drugs of sleeping sickness: their mechanisms of action and resistance, and a brief history. Tropical Medicine and Infectious Disease, 5(1), 14. (doi: 10.3390/tropicalmed5010014)

[img]
Preview
Text
206482.pdf - Published Version
Available under License Creative Commons Attribution.

674kB

Abstract

With the incidence of sleeping sickness in decline and genuine progress being made towards the WHO goal of eliminating sleeping sickness as a major public health concern, this is a good moment to evaluate the drugs that ‘got the job done’: their development, their limitations and the resistance that the parasites developed against them. This retrospective looks back on the remarkable story of chemotherapy against trypanosomiasis, a story that goes back to the very origins and conception of chemotherapy in the first years of the 20 century and is still not finished today.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:De Koning, Professor Harry
Authors: De Koning, H. P.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Tropical Medicine and Infectious Disease
Publisher:MDPI
ISSN:2414-6366
ISSN (Online):2414-6366
Copyright Holders:Copyright © 2020 The Author
First Published:First published in Tropical Medicine and Infectious Disease 5(1):14
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record