Bacigalupe, R., Tormo-Mas, M. Á., Penades, J. R. and Fitzgerald, J. R. (2019) A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species. Science Advances, 5(11), eaax0063. (doi: 10.1126/sciadv.aax0063) (PMID:31807698) (PMCID:PMC6881152)
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Abstract
While many bacterial pathogens are restricted to single host species, some have the capacity to undergo host switches, leading to the emergence of new clones that are a threat to human and animal health. However, the bacterial traits that underpin a multihost ecology are not well understood. Following transmission to a new host, bacterial populations are influenced by powerful forces such as genetic drift that reduce the fixation rate of beneficial mutations, limiting the capacity for host adaptation. Here, we implement a novel experimental model of bacterial host switching to investigate the ability of the multihost pathogen to adapt to new species under continuous population bottlenecks. We demonstrate that beneficial mutations accumulated during infection can overcome genetic drift and sweep through the population, leading to host adaptation. Our findings highlight the remarkable capacity of some bacteria to adapt to distinct host niches in the face of powerful antagonistic population forces.
Item Type: | Articles |
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Additional Information: | The study was supported by a project grant (BB/K00638X/1) and institute strategic grant funding ISP2: BB/P013740/1 from the Biotechnology and Biological Sciences Research Council (United Kingdom) to J.R.F.; grant MR/N02995X/1 from the Medical Research Council (United Kingdom) to J.R.F; Wellcome Trust collaborative award 201531/Z/16/Z to J.R.F. and J.R.P.; grants MR/M003876/1 and MR/S00940X/1 from the Medical Research Council (United Kingdom); BB/N002873/1 and BB/S003835/1 from the Biotechnology and Biological Sciences Research Council (BBSRC; United Kingdom); ERC-ADG-2014 proposal no. 670932 Dut-signal from EU to J.R.P.; and grants RTA2011-00139-00-00 from the Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria of Spain and SAF2017-82251-R and CSD2009-00006 from the Ministerio de Ciencia, Innovación y Universidades of Spain to M.Á.T.-M. J.R.P. is thankful to the Royal Society and the Wolfson Foundation for providing support through a Royal Society Wolfson Fellowship |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Penades, Prof Jose R |
Authors: | Bacigalupe, R., Tormo-Mas, M. Á., Penades, J. R., and Fitzgerald, J. R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Science Advances |
Publisher: | American Association for the Advancement of Science |
ISSN: | 2375-2548 |
ISSN (Online): | 2375-2548 |
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