Moyes, L.H., Hamid, R., Clutton, J., Oien, K.A. , McKee, R.F. and Forrest, E.H. (2012) Improvement of parenteral nutrition-associated cholestasis in an adult using fish oil-based parenteral nutrition. Frontline Gastroenterology, 3(2), pp. 94-97. (doi: 10.1136/flgastro-2011-100056) (PMID:28839644) (PMCID:PMC5517263)
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Abstract
Parenteral nutrition-associated cholestasis (PNAC) is a severe complication of parenteral nutrition. Standard feed preparations contain soybean and olive oil that are rich in ω-6 polyunsaturated fats, and which studies suggest can be hepatotoxic. Preparations containing fish oil, rich in ω-3 polyunsaturated fats, may be hepatoprotective and have been used in the critical care setting as immunotherapy. A case demonstrating dramatic improvement in liver function and overall clinical condition in an adult with PNAC and intestinal failure within 8 weeks of changing to a fish oil-based parenteral feed is reported. As far as is known, this is the first report of an adult patient whose parenteral nutrition-associated liver disease resolved after a parenteral nutrition lipid emulsion was changed to the fish oil-containing emulsion, SMOFlipid.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McKee, Dr Ruth and Oien, Professor Karin and Moyes, Dr Lisa and Forrest, Dr Ewan |
| Authors: | Moyes, L.H., Hamid, R., Clutton, J., Oien, K.A., McKee, R.F., and Forrest, E.H. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Frontline Gastroenterology |
| Publisher: | BMJ Publishing Group |
| ISSN: | 2041-4137 |
| ISSN (Online): | 2041-4145 |
| Published Online: | 13 March 2012 |
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