Crispell, J. et al. (2019) Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system. eLife, 8, e45833. (doi: 10.7554/elife.45833) (PMID:31843054) (PMCID:PMC6917503)
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206218.pdf - Published Version Available under License Creative Commons Attribution. 8MB |
Abstract
Quantifying pathogen transmission in multi-host systems is difficult, as exemplified in bovine tuberculosis (bTB) systems, but is crucial for control. The agent of bTB, Mycobacterium bovis, persists in cattle populations worldwide, often where potential wildlife reservoirs exist. However, the relative contribution of different host species to bTB persistence is generally unknown. In Britain, the role of badgers in infection persistence in cattle is highly contentious, despite decades of research and control efforts. We applied Bayesian phylogenetic and machine-learning approaches to bacterial genome data to quantify the roles of badgers and cattle in M. bovis infection dynamics in the presence of data biases. Our results suggest that transmission occurs more frequently from badgers to cattle than vice versa (10.4x in the most likely model) and that within-species transmission occurs at higher rates than between-species transmission for both. If representative, our results suggest that control operations should target both cattle and badgers.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Trewby, Dr Hannah and Allen, Dr Adrian and Kao, Professor Rowland and Skuce, Professor Robin and Lycett, Dr Samantha and Balaz, Dr Daniel and Biek, Professor Roman and Zadoks, Professor Ruth and Crispell, Mr Joseph |
| Creator Roles: | Crispell, J.Formal analysis, Visualization, Methodology, Writing – original draft, Writing – review and editing Trewby, H.Data curation, Writing – review and editing Balaz, D.Methodology, Writing – review and editing Biek, R.Methodology, Writing – review and editing Lycett, S. J.Methodology, Writing – review and editing Allen, A.Data curation, Writing – review and editing Skuce, R. A.Data curation, Writing – review and editing Zadoks, R. N.Supervision, Methodology, Writing – review and editing Kao, R. R.Conceptualization, Data curation, Supervision, Funding acquisition, Methodology, Writing – review and editing |
| Authors: | Crispell, J., Benton, C. H., Balaz, D., De Maio, N., Ahkmetova, A., Allen, A., Biek, R., Presho, E. L., Dale, J., Hewinson, G., Lycett, S. J., Nunez-Garcia, J., Skuce, R. A., Trewby, H., Wilson, D. J., Zadoks, R. N., Delahay, R. J., and Kao, R. R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | eLife |
| Publisher: | eLife Sciences Publications |
| ISSN: | 2050-084X |
| ISSN (Online): | 2050-084X |
| Copyright Holders: | Copyright © 2019 Crispell et al. |
| First Published: | First published in eLife 8: e45833 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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