Magnesium, vascular function, and hypertension

Rios, F. J. , Montezano, A. C., Antunes, T. T. and Touyz, R. M. (2016) Magnesium, vascular function, and hypertension. In: Collins, J. F. (ed.) Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Academic Press, pp. 353-364. ISBN 9780128021682 (doi: 10.1016/B978-0-12-802168-2.00029-4)

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Magnesium is an essential cation critically involved in cell viability and physiological regulation of all systems and organs. In the cardiovascular system it modulates mechanical, electrical, and structural functions of cardiac and vascular cells, and small changes in extracellular magnesium levels and/or intracellular free magnesium concentration may have profound effects on cardiac excitability, vascular tone, contractility, and reactivity. Magnesium homeostasis is tightly regulated through intestinal absorption and renal excretion and involves specific magnesium transporters, including transient receptor potential melastatin cation channels-6 and -7 and magnesium transporter subtype 1. Perturbations in magnesium metabolism may lead to cellular magnesium deficiency, which has been associated with various pathologies, including cardiovascular disease. This chapter discusses the cellular, physiological, and pharmacological roles of magnesium in the regulation of vascular function and implications of altered magnesium homeostasis in cardiovascular diseases, focusing on hypertension.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Rios, Dr Francisco and Montezano, Dr Augusto and Touyz, Professor Rhian
Authors: Rios, F. J., Montezano, A. C., Antunes, T. T., and Touyz, R. M.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Publisher:Academic Press

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