Subbiah, M. et al. (2020) Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania. Nature Communications, 11, 228. (doi: 10.1038/s41467-019-13995-5) (PMID:31932601) (PMCID:PMC6957491)
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Abstract
Antibiotic use and bacterial transmission are responsible for the emergence, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relative contribution likely differs across varying socio-economic, cultural, and ecological contexts. To better understand this interaction in a multi-cultural and resource-limited context, we examine the distribution of antimicrobial-resistant enteric bacteria from three ethnic groups in Tanzania. Household-level data (n = 425) was collected and bacteria isolated from people, livestock, dogs, wildlife and water sources (n = 62,376 isolates). The relative prevalence of different resistance phenotypes is similar across all sources. Multi-locus tandem repeat analysis (n = 719) and whole-genome sequencing (n = 816) of Escherichia coli demonstrate no evidence for host-population subdivision. Multivariate models show no evidence that veterinary antibiotic use increased the odds of detecting AR bacteria, whereas there is a strong association with livelihood factors related to bacterial transmission, demonstrating that to be effective, interventions need to accommodate different cultural practices and resource limitations.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mair, Dr Colette and Matthews, Professor Louise |
| Authors: | Subbiah, M., Caudell, M. A., Mair, C., Davis, M. A., Matthews, L., Quinlan, R. J., Quinlan, M. B., Lyimo, B., Buza, J., Keyyu, J., and Call, D. R. |
| College/School: | College of Science and Engineering > School of Mathematics and Statistics > Statistics College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Nature Communications |
| Publisher: | Nature Publishing Group |
| ISSN: | 2041-1723 |
| ISSN (Online): | 2041-1723 |
| Published Online: | 13 January 2020 |
| Copyright Holders: | Copyright © The Authors 2020 |
| First Published: | First published in Nature Communications 11:228 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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