Jarvie, E., Stewart, F., Ramsay, J. E., Brown, E. A., Meyer, B., Olivecrona, G., Griffin, B. and Freeman, D. (2020) Maternal adipose tissue expansion, a missing link in the prediction of birth weight centile. Journal of Clinical Endocrinology and Metabolism, 105(3), e814-e825. (doi: 10.1210/clinem/dgz248) (PMID:31832635)
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Abstract
Context: Maternal body mass index (BMI) is associated with increased birth weight but does not explain all the variance in fetal adiposity. Objective: To assess the contribution of maternal body fat distribution to offspring birth weight and adiposity. Design: Longitudinal study throughout gestation and at delivery. Setting: Women recruited at 12 weeks of gestation and followed up at 26 and 36 weeks. Cord blood was collected at delivery. Patients: Pregnant women (n=45) with BMI 18.0-46.3 kg/m2 and healthy pregnancy outcome. Methods: Maternal first trimester abdominal subcutaneous and visceral adipose tissue thickness (SAT and VAT) was assessed by ultrasound. Results: VAT was the only anthropometric measure independently associated with birth weight centile (r2 adjusted 15.8%, P=0.002). BMI was associated with trimester 2 and trimester 1 – 3 area under the curve (AUC) glucose and insulin resistance (HOMA). SAT alone predicted trimester 2 lipoprotein lipase (LPL) mass (a marker of adipocyte insulin sensitivity) (11.3%, P=0.017). VAT was associated with fetal triglyceride (9.3%, P=0.047). Placental weight was the only independent predictor of fetal adiposity (48%, P<0.001). Maternal trimester 2 and AUC LPL were inversely associated with fetal adiposity (r=-0.69, P=0.001 and r=-0.58, P=0.006 respectively). Conclusions: Maternal VAT provides additional information to BMI for prediction of birth weight. VAT may be a marker of reduced SAT expansion and increased availability of maternal fatty acids for placental transport.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Freeman, Dr Dilys and Meyer, Ms Barbara and Ramsay, Dr Jane and Jarvie, Dr Eleanor |
Authors: | Jarvie, E., Stewart, F., Ramsay, J. E., Brown, E. A., Meyer, B., Olivecrona, G., Griffin, B., and Freeman, D. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Journal of Clinical Endocrinology and Metabolism |
Publisher: | Oxford University Press |
ISSN: | 0021-972X |
ISSN (Online): | 1945-7197 |
Published Online: | 13 December 2019 |
Copyright Holders: | Copyright © Endocrine Society 2019 |
First Published: | First published in Journal of Clinical Endocrinology and Metabolism 105(3):e814-e825 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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