Exosomes and other extracellular vesicles: the new communicators in parasite infections

Coakley, G., Maizels, R. M. and Buck, A. H. (2015) Exosomes and other extracellular vesicles: the new communicators in parasite infections. Trends in Parasitology, 31(10), pp. 477-489. (doi: 10.1016/j.pt.2015.06.009) (PMID:26433251) (PMCID:PMC4685040)

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Abstract

Extracellular vesicles (EVs) have emerged as a ubiquitous mechanism for transferring information between cells and organisms across all three kingdoms of life. In addition to their roles in normal physiology, vesicles also transport molecules from pathogens to hosts and can spread antigens as well as infectious agents. Although initially described in the host-pathogen context for their functions in immune surveillance, vesicles enable multiple modes of communication by, and between, parasites. Here we review the literature demonstrating that EVs are secreted by intracellular and extracellular eukaryotic parasites, as well as their hosts, and detail the functional properties of these vesicles in maturation, pathogenicity and survival. We further describe the prospects for targeting or exploiting these complexes in therapeutic and vaccine strategies.

Item Type:Articles
Additional Information:R.M.M.’s laboratory is supported by the Wellcome Trust through a programme grant (090281/Z/09/Z) and a Senior Investigator Award (106122/Z/14/Z) and by the Rainin Foundation (12H4). A.H.B.’s laboratory is supported by Wellcome Trust RCDF (WT097394A1A) and HFSP (RGY0069) project grants. All authors are supported by the Wellcome Trust-funded Centre for Immunity, Infection, and Evolution (095831/Z/11/Z).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maizels, Professor Rick
Authors: Coakley, G., Maizels, R. M., and Buck, A. H.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Trends in Parasitology
Publisher:Elsevier
ISSN:1471-4922
ISSN (Online):1471-5007
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Trends in Parasitology 31(10):477-489
Publisher Policy:Reproduced under a Creative Commons license

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