McSorley, H. J., Blair, N. F., Robertson, E. and Maizels, R. M. (2015) Suppression of OVA-alum induced allergy by Heligmosomoides polygyrus products is MyD88-, TRIF-, regulatory T- and B cell-independent, but is associated with reduced innate lymphoid cell activation. Experimental Parasitology, 158, pp. 8-17. (doi: 10.1016/j.exppara.2015.02.009) (PMID:25728231) (PMCID:PMC6485390)
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Abstract
The murine intestinal nematode Heligmosomoides polygyrus exerts multiple immunomodulatory effects in the host, including the suppression of allergic inflammation in mice sensitized to allergen presented with alum adjuvant. Similar suppression is attained by co-administration of H. polygyrus excretory/secretory products (HES) with the sensitizing dose of ovalbumin (OVA) in alum. We investigated the mechanism of suppression by HES in this model, and found it was maintained in MyD88xTRIF-deficient mice, implying no role for helminth- or host-derived TLR ligands, or IL-1 family cytokines that signal in a MyD88- or TRIF-dependent manner. We also found suppression was unchanged in µMT mice, which lack B2 B cells, and that suppression was not abrogated when regulatory T cells were depleted in Foxp3.LuciDTR-4 mice. However, reduced IL-5 production was seen in the first 12 h after injection of OVA-alum when HES was co-administered, associated with reduced activation of IL-5+ and IL-13+ group 2 innate lymphoid cells. Thus, the suppressive effects of HES on alum-mediated OVA sensitization are reflected in the very earliest innate response to allergen exposure in vivo.
Item Type: | Articles |
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Additional Information: | Funding from the American Asthma Foundation (all authors, grant number 10-0234), Asthma UK (HMcS, grant number AUK-SPD-2012-172) and the Wellcome Trust (RMM, grant number 090281). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Maizels, Professor Rick |
Authors: | McSorley, H. J., Blair, N. F., Robertson, E., and Maizels, R. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Experimental Parasitology |
Publisher: | Elsevier |
ISSN: | 0014-4894 |
ISSN (Online): | 1090-2449 |
Published Online: | 26 February 2015 |
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