Reynolds, L. A., Finlay, B. B. and Maizels, R. M. (2015) Cohabitation in the intestine: interactions among helminth parasites, bacterial microbiota, and host immunity. Journal of Immunology, 195(9), pp. 4059-4066. (doi: 10.4049/jimmunol.1501432) (PMID:26477048) (PMCID:PMC4617609)
Full text not currently available from Enlighten.
Abstract
Both intestinal helminth parasites and certain bacterial microbiota species have been credited with strong immunomodulatory effects. Recent studies reported that the presence of helminth infection alters the composition of the bacterial intestinal microbiota and, conversely, that the presence and composition of the bacterial microbiota affect helminth colonization and persistence within mammalian hosts. This article reviews recent findings on these reciprocal relationships, in both human populations and mouse models, at the level of potential mechanistic pathways and the implications these bear for immunomodulatory effects on allergic and autoimmune disorders. Understanding the multidirectional complex interactions among intestinal microbes, helminth parasites, and the host immune system allows for a more holistic approach when using probiotics, prebiotics, synbiotics, antibiotics, and anthelmintics, as well as when designing treatments for autoimmune and allergic conditions.
| Item Type: | Articles |
|---|---|
| Additional Information: | B.B.F. was supported by operating grants from the Canadian Institutes of Health Research, including a Canadian Institutes of Health Research Emerging Team Grant in partnership with Genome British Columbia and the AllerGen NCE. R.M.M. is supported by grants from the Rainin Foundation (Grant 12-H4) and the Wellcome Trust (Grant 106122). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Maizels, Professor Rick |
| Authors: | Reynolds, L. A., Finlay, B. B., and Maizels, R. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of Immunology |
| Publisher: | American Association of Immunologists |
| ISSN: | 0022-1767 |
| ISSN (Online): | 1550-6606 |
| Published Online: | 16 October 2015 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details