Cantini, M. , Donnelly, H., Dalby, M. J. and Salmeron-Sanchez, M. (2020) The plot thickens: the emerging role of matrix viscosity in cell mechanotransduction. Advanced Healthcare Materials, 9(8), 1901259. (doi: 10.1002/adhm.201901259) (PMID:31815372)
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Abstract
Cell mechanotransduction is an area of intense research focus. Until now, very limited tools have existed to study how cells respond to changes in the extracellular matrix beyond, for example, mechanical deformation studies and twisting cytometry. However, emerging are a range of elastic, viscoelastic and even purely viscous materials that deform and dissipate on cellular length and timescales. This article reviews developments in these materials, typically translating from 2D model surfaces to 3D microenvironments and explores how cells interact with them. Specifically, it focuses on emerging concepts such as the molecular clutch model, how different extracellular matrix proteins engage the clutch under viscoelastic‐stress relaxation conditions, and how mechanotransduction can drive transcriptional control through regulators such as YAP/TAZ.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew and Donnelly, Dr Hannah and Cantini, Dr Marco |
| Authors: | Cantini, M., Donnelly, H., Dalby, M. J., and Salmeron-Sanchez, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Advanced Healthcare Materials |
| Publisher: | Wiley |
| ISSN: | 2192-2640 |
| ISSN (Online): | 2192-2659 |
| Published Online: | 09 December 2019 |
| Copyright Holders: | Copyright © 2019 The Authors |
| First Published: | First published in Advanced Healthcare Materials 9(8):1901259 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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