Moderate intensity exercise training combined with inulin-propionate ester supplementation increases whole body resting fat oxidation in overweight women

Malkova, D. , Polyviou, T., Rizou, E., Gerasimidis, K. , Chambers, E. S., Preston, T. , Tedford, C. M., Frost, G. and Morrison, D. J. (2020) Moderate intensity exercise training combined with inulin-propionate ester supplementation increases whole body resting fat oxidation in overweight women. Metabolism, 104, 154043. (doi: 10.1016/j.metabol.2019.154043) (PMID:31790692)

Abstract

Background: Our previous work has shown that oral supplementation with inulin propionate ester (IPE) reduces intra-abdominal fat and prevents weight gain and that oral propionate intake enhances resting fat oxidation. The effects of IPE combined with exercise training on energy substrate utilisation are unknown. The aim of this study was to investigate the impact of 4-weeks IPE supplementation, in combination with a moderate intensity exercise training programme, on whole body fat oxidation and on plasma GLP-1 and PYY. Methods: Twenty overweight healthy women participated in randomised parallel study and underwent 4 weeks of supervised exercise training either with IPE (EX/IPE group) or Placebo (EX/Placebo group) supplementation. Before and after the intervention participants conducted an experimental trial, which involved collection of expired gas and blood samples in the fasted state and during 7 h of the postprandial state. Results: Within groups, the EX/IPE group significantly enhanced the amount of fat (Pre, 24.1 ± 1.2 g; Post, 35.9 ± 4.0 g, P < .05) oxidised and reduced CHO (Pre, 77.8 ± 6.0 g; Post, 57.8 ± 7.7 g, P < .05) oxidised, reduced body weight (Pre, 77.3 ± 4.2 kg; Post, 76.6 ± 4.1 kg, P < .05) and body fat mass (Pre, 37.7 ± 1.9%; Post, 36.9 ± 1.9%, P < .05). In EX/Placebo group, changes in amount of fat (Pre, 36.8 ± 3.9 g; Post, 37.0 ± 4.0 g) and CHO (Pre, 62.7 ± 6.5 g; Post, 61.5 ± 7.4 g) oxidised, body weight (Pre, 84.2 ± 4.3 kg; Post, 83.6 ± 4.3 kg) and body fat mass (Pre, 40.1 ± 1.9%; Post, 38.7 ± 1.5%) were not significant (P > .05). Comparing between groups, changes in the amount of fat oxidised were significantly (P < .05) different and a trend for difference was observed for amount of CHO oxidised (P = .06) and RER (P = .06). The interventions had no impact on fasting or postprandial plasma concentrations of GLP-1 and PYY. Conclusion: Moderate intensity exercise training programmes when combined with daily oral IPE supplementation may help overweight women to achieve increase in fat oxidation. The study was registered at clinicaltrials.gov as NCT04016350.

• Item Type: Articles
• Additional Information: This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC; Grant No. BB/L004259/1).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Malkova, Dr Dalia and Morrison, Dr Douglas and Preston, Professor Tom and Rizou, Miss Eleni and Gerasimidis, Professor Konstantinos and Polyviou, Dr Thelma
• Authors: Malkova, D., Polyviou, T., Rizou, E., Gerasimidis, K., Chambers, E. S., Preston, T., Tedford, C. M., Frost, G., and Morrison, D. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Science and Engineering > Scottish Universities Environmental Research Centre
• Journal Name: Metabolism
• Publisher: Elsevier
• ISSN: 0026-0495
• ISSN (Online): 1532-8600
• Published Online: 29 November 2019
• Copyright Holders: Copyright © 2019 Elsevier Inc.
• First Published: First published in Metabolism 104: 154043
• Publisher Policy: Reproduced in accordance with the publisher copyright policy