Comparing the interobserver reproducibility of different regions of interest on multi-parametric renal magnetic resonance imaging in healthy volunteers, patients with heart failure and renal transplant recipients

Rankin, A. J. et al. (2020) Comparing the interobserver reproducibility of different regions of interest on multi-parametric renal magnetic resonance imaging in healthy volunteers, patients with heart failure and renal transplant recipients. Magnetic Resonance Materials in Physics, Biology and Medicine, 33, pp. 103-112. (doi: 10.1007/s10334-019-00809-4) (PMID:31823275) (PMCID:PMC7021749)

Abstract

Objective: To assess interobserver reproducibility of different regions of interest (ROIs) on multi-parametric renal MRI using commercially available software. Materials and methods: Healthy volunteers (HV), patients with heart failure (HF) and renal transplant recipients (Tx) were recruited. Localiser scans, T1 mapping and pseudo-continuous arterial spin labelling (pCASL) were performed. HV and Tx also underwent diffusion-weighted imaging to allow calculation of apparent diffusion coefficient (ADC). For T1, pCASL and ADC, ROIs were drawn for whole kidney (WK), cortex (Cx), user-defined representative cortex (rep-Cx) and medulla. Intraclass correlation coefficient (ICC) and coefficient of variation (CoV) were assessed. Results: Forty participants were included (10 HV, 10 HF and 20 Tx). The ICC for renal volume was 0.97 and CoV 6.5%. For T1 and ADC, WK, Cx, and rep-Cx were highly reproducible with ICC ≥ 0.76 and CoV < 5%. However, cortical pCASL results were more variable (ICC > 0.86, but CoV up to 14.2%). While reproducible, WK values were derived from a wide spread of data (ROI standard deviation 17% to 55% of the mean value for ADC and pCASL, respectively). Renal volume differed between groups (p < 0.001), while mean cortical T1 values were greater in Tx compared to HV (p = 0.009) and HF (p = 0.02). Medullary T1 values were also higher in Tx than HV (p = 0.03), while medullary pCASL values were significantly lower in Tx compared to HV and HF (p = 0.03 for both). Discussion: Kidney volume calculated by manually contouring a localiser scan was highly reproducible between observers and detected significant differences across patient groups. For T1, pCASL and ADC, Cx and rep-Cx ROIs are generally reproducible with advantages over WK values.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Woodward, Miss Rosemary and Roditi, Dr Giles and Lee, Matthew and Mark, Professor Patrick and Gillis, Dr Keith and Rankin, Dr Alastair and Allwood-Spiers, Sarah and Sattar, Professor Naveed and Radjenovic, Dr Aleksandra
• Authors: Rankin, A. J., Allwood-Spiers, S., Lee, M. M.Y., Zhu, L., Woodward, R., Kuehn, B., Radjenovic, A., Sattar, N., Roditi, G., Mark, P. B., and Gillis, K. A.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Magnetic Resonance Materials in Physics, Biology and Medicine
• Publisher: Springer
• ISSN: 0968-5243
• ISSN (Online): 1352-8661
• Published Online: 10 December 2019
• Copyright Holders: Copyright © 2019 The Authors
• First Published: First published in Magnetic Resonance Materials in Physics, Biology and Medicine 33:103-112
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
303352		INTERROGATION OF THE CARDIOMYOPATHY OF CHRONIC KIDNEY DISEASE WITH ADVANCED CARDIAC IMAGING	Alastair Rankin	Chief Scientist Office (CSO)	CAF/18/02	CAMS - Cardiovascular Science
305405		A clinical-pathological study into the diagnostic utility of multiparametric MRI in the setting of kidney transplant dysfunction	Patrick Mark	Kidney Research UK (KIDNEYRE)	KS_IN_002_20180913	CAMS - Cardiovascular Science