Grey-matter abnormalities in clinical high-risk participants for psychosis

Zikidi, K., Gajwani, R. , Gross, J. , Gumley, A. I. , Lawrie, S. M., Schwannauer, M., Schultze-Lutter, F., Fracasso, A. and Uhlhaas, P. J. (2020) Grey-matter abnormalities in clinical high-risk participants for psychosis. Schizophrenia Research, 226, pp. 120-128. (doi: 10.1016/j.schres.2019.08.034) (PMID:31740178) (PMCID:PMC7774586)

Abstract

The current study examined the presence of abnormalities in cortical grey-matter (GM) in a sample of clinical high-risk (CHR) participants and examined relationships with psychosocial functioning and neurocognition. CHR-participants (n = 114), participants who did not fulfil CHR-criteria (CHR-negative) (n = 39) as well as a group of healthy controls (HC) (n = 49) were recruited. CHR-status was assessed using the Comprehensive Assessment of At-Risk Mental State (CAARMS) and the Schizophrenia Proneness Interview, Adult Version (SPI-A). The Brief Assessment of Cognition in Schizophrenia Battery (BACS) as well as tests for emotion recognition, working memory and attention were administered. In addition, role and social functioning as well as premorbid adjustment were assessed. No significant differences in GM-thickness and intensity were observed in CHR-participants compared to CHR-negative and HC. Circumscribed abnormalities in GM-intensity were found in the visual and frontal cortex of CHR-participants. Moreover, small-to-moderate correlations were observed between GM-intensity and neuropsychological deficits in the CHR-group. The current data suggest that CHR-participants may not show comprehensive abnormalities in GM. We discuss the implications of these findings for the pathophysiological theories of early stage-psychosis as well as methodological issues and the impact of different recruitment strategies.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Uhlhaas, Professor Peter and Zikidi, Miss Aikaterini and Fracasso, Dr Alessio and Gajwani, Dr Ruchika and Gross, Professor Joachim and Gumley, Professor Andrew
• Authors: Zikidi, K., Gajwani, R., Gross, J., Gumley, A. I., Lawrie, S. M., Schwannauer, M., Schultze-Lutter, F., Fracasso, A., and Uhlhaas, P. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing; College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Schizophrenia Research
• Publisher: Elsevier
• ISSN: 0920-9964
• ISSN (Online): 1573-2509
• Published Online: 15 November 2019
• Copyright Holders: Copyright © 2019 The Authors
• First Published: First published in press in Schizophrenia Research 226: 120-128
• Publisher Policy: Reproduced under a Creative Commons Licence

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
190713		Using Magnetoencephalography to Investigate Aberrant Neural Synchrony in Prodromal Schizophrenia: A Translational Biomarker Approach	Peter Uhlhaas	Medical Research Council (MRC)	MR/L011689/1	NP - Centre for Cognitive Neuroimaging (CCNi)