Grey-matter abnormalities in clinical high-risk participants for psychosis

Zikidi, K., Gajwani, R. , Gross, J. , Gumley, A. I. , Lawrie, S. M., Schwannauer, M., Schultze-Lutter, F., Fracasso, A. and Uhlhaas, P. J. (2020) Grey-matter abnormalities in clinical high-risk participants for psychosis. Schizophrenia Research, 226, pp. 120-128. (doi: 10.1016/j.schres.2019.08.034) (PMID:31740178) (PMCID:PMC7774586)

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The current study examined the presence of abnormalities in cortical grey-matter (GM) in a sample of clinical high-risk (CHR) participants and examined relationships with psychosocial functioning and neurocognition. CHR-participants (n = 114), participants who did not fulfil CHR-criteria (CHR-negative) (n = 39) as well as a group of healthy controls (HC) (n = 49) were recruited. CHR-status was assessed using the Comprehensive Assessment of At-Risk Mental State (CAARMS) and the Schizophrenia Proneness Interview, Adult Version (SPI-A). The Brief Assessment of Cognition in Schizophrenia Battery (BACS) as well as tests for emotion recognition, working memory and attention were administered. In addition, role and social functioning as well as premorbid adjustment were assessed. No significant differences in GM-thickness and intensity were observed in CHR-participants compared to CHR-negative and HC. Circumscribed abnormalities in GM-intensity were found in the visual and frontal cortex of CHR-participants. Moreover, small-to-moderate correlations were observed between GM-intensity and neuropsychological deficits in the CHR-group. The current data suggest that CHR-participants may not show comprehensive abnormalities in GM. We discuss the implications of these findings for the pathophysiological theories of early stage-psychosis as well as methodological issues and the impact of different recruitment strategies.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter and Zikidi, Miss Aikaterini and Fracasso, Dr Alessio and Gajwani, Dr Ruchika and Gross, Professor Joachim and Gumley, Professor Andrew
Authors: Zikidi, K., Gajwani, R., Gross, J., Gumley, A. I., Lawrie, S. M., Schwannauer, M., Schultze-Lutter, F., Fracasso, A., and Uhlhaas, P. J.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Schizophrenia Research
ISSN (Online):1573-2509
Published Online:15 November 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in press in Schizophrenia Research 226: 120-128
Publisher Policy:Reproduced under a Creative Commons Licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190713Using Magnetoencephalography to Investigate Aberrant Neural Synchrony in Prodromal Schizophrenia: A Translational Biomarker ApproachPeter UhlhaasMedical Research Council (MRC)MR/L011689/1NP - Centre for Cognitive Neuroimaging (CCNi)