Subgroup analyses in cost-effectiveness analyses to support health technology assessments

Fletcher, C., Chuang-Stein, C., Paget, M.-A., Reid, C. and Hawkins, N. (2014) Subgroup analyses in cost-effectiveness analyses to support health technology assessments. Pharmaceutical Statistics, 13(4), pp. 265-274. (doi: 10.1002/pst.1626) (PMID:24931490)

Full text not currently available from Enlighten.


‘Success’ in drug development is bringing to patients a new medicine that has an acceptable benefit–risk profile and that is also cost‐effective. Cost‐effectiveness means that the incremental clinical benefit is deemed worth paying for by a healthcare system, and it has an important role in enabling manufacturers to obtain new medicines to patients as soon as possible following regulatory approval. Subgroup analyses are increasingly being utilised by decision‐makers in the determination of the cost‐effectiveness of new medicines when making recommendations. This paper highlights the statistical considerations when using subgroup analyses to support cost‐effectiveness for a health technology assessment. The key principles recommended for subgroup analyses supporting clinical effectiveness published by Paget et al. are evaluated with respect to subgroup analyses supporting cost‐effectiveness. A health technology assessment case study is included to highlight the importance of subgroup analyses when incorporated into cost‐effectiveness analyses. In summary, we recommend planning subgroup analyses for cost‐effectiveness analyses early in the drug development process and adhering to good statistical principles when using subgroup analyses in this context. In particular, we consider it important to provide transparency in how subgroups are defined, be able to demonstrate the robustness of the subgroup results and be able to quantify the uncertainty in the subgroup analyses of cost‐effectiveness.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hawkins, Professor Neil
Authors: Fletcher, C., Chuang-Stein, C., Paget, M.-A., Reid, C., and Hawkins, N.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment
Journal Name:Pharmaceutical Statistics
ISSN (Online):1539-1612
Published Online:15 June 2014

University Staff: Request a correction | Enlighten Editors: Update this record