Synthesizing clinical evidence for economic evaluation

Hawkins, N. (2014) Synthesizing clinical evidence for economic evaluation. In: Culyer, A. J. (ed.) Encyclopedia of Health Economics. Elsevier, pp. 382-385. ISBN 9780123756794 (doi: 10.1016/B978-0-12-375678-7.01404-8)

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A key aspect of economic evaluation is the estimation of clinical parameters, in particular relating to treatment effects. Network meta-analysis is an extension of pairwise meta analysis that provides estimates of the relative effectiveness of two or more treatments. These are derived from a statistical analysis of a connected network of clinical trial comparisons. Estimates are obtained that correspond to a consistency constraint on the treatment effect scale used for the analysis (δAB=δAC−δBC), where δAB is the indirect estimate of the effect of treatment A compared with treatment B and δAC and δBB represent the direct estimates of the effects of A versus C and B versus C, respectively, and best fit the treatment effect estimates from individual trials.

Item Type:Book Sections (Encyclopaedia entry)
Glasgow Author(s) Enlighten ID:Hawkins, Professor Neil
Authors: Hawkins, N.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment
Journal Name:Encyclopedia of Health Economics

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