CAF subpopulations: a new reservoir of stromal targets in pancreatic cancer

Pereira, B. A., Vennin, C., Papanicolaou, M., Chambers, C. R., Herrmann, D., Morton, J. P. , Cox, T. R. and Timpson, P. (2019) CAF subpopulations: a new reservoir of stromal targets in pancreatic cancer. Trends in Cancer, 5(11), pp. 724-741. (doi: 10.1016/j.trecan.2019.09.010) (PMID:31735290)

[img]
Preview
Text
203395.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

3MB

Abstract

Cancer-associated fibroblasts (CAFs) are one of the most significant components in the tumour microenvironment (TME), where they can perform several protumourigenic functions. Several studies have recently reported that CAFs are more heterogenous and plastic than was previously thought. As such, there has been a shift in the field to study CAF subpopulations and the emergent functions of these subsets in tumourigenesis. In this review, we explore how different aspects of CAF heterogeneity are defined and how these manifest in multiple cancers, with a focus on pancreatic ductal adenocarcinoma (PDAC). We also discuss therapeutic approaches to selectively target protumourigenic CAF functions, while avoiding normal fibroblasts, providing insight into the future of stromal targeting for the treatment of PDAC and other solid tumours.

Item Type:Articles
Additional Information:C.V. is supported by a Human Frontier Science Program (HFSP) fellowship. M.P. and C.R.C. are supported by an Australian Government Research Training Program (RTP) Scholarship. J.P.M. is supported by Cancer Research UK. T.R.C. is supported by an NHMRC R.D. Wright Biomedical Career Development Fellowship and a grant from Susan G. Komen. P.T. is supported by the Len Ainsworth Fellowship in Pancreatic Cancer Research and is a National Health and Medical Research Council (NHMRC) Senior Research Fellow. This work was made possible by an Avner Pancreatic Cancer Foundation Grant. This work was supported by Suttons, Sydney Catalyst, Australian Research Council (ARC), NHMRC, Cancer Council NSW, Cancer Institute NSW, National Breast Cancer Foundation (NBCF), St. Vincent’s Clinic Foundation.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morton, Professor Jen
Authors: Pereira, B. A., Vennin, C., Papanicolaou, M., Chambers, C. R., Herrmann, D., Morton, J. P., Cox, T. R., and Timpson, P.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Trends in Cancer
Publisher:Elsevier
ISSN:2405-8025
ISSN (Online):2405-8033
Published Online:21 October 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Trends in Cancer 5(11):724-741
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record