Pimlott, S. L. , Piggott, M., Patterson, J., Cavanagh, J. and Wyper, D. J. (2007) SPECT imaging of the α4β2 nicotinic receptor using [5-123I]A85380. Journal of Labelled Compounds and Radiopharmaceuticals, 50(5-6), pp. 350-353. (doi: 10.1002/jlcr.1192)
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Abstract
In order to image nAChR density in vivo in humans, [5-<sup>123</sup>I]-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine ([5-<sup>123</sup>I]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, <i>in vitro</i> validation in human post-mortem tissue and some initial <i>in vivo</i> clinical studies using the ligand [5-<sup>123/125</sup>I]A85380. Limitations of the usefulness of the tracer for routine clinical use are also discussed.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Patterson, Dr James and Wyper, Professor David and Pimlott, Dr Sally and Cavanagh, Professor Jonathan |
| Authors: | Pimlott, S. L., Piggott, M., Patterson, J., Cavanagh, J., and Wyper, D. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities |
| Journal Name: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Publisher: | John Wiley & Sons, Ltd. |
| ISSN: | 0362-4803 |
| ISSN (Online): | 1099-1344 |
| Published Online: | 30 July 2007 |
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