Effect of oxandrolone and timing of pubertal induction on final height in Turner syndrome: final analysis of the UK randomised placebo-controlled trial

Gault, E. J., Cole, T. J., Casey, S., Hindmarsh, P. C., Betts, P., Dunger, D. B. and Donaldson, M. D.C. (2019) Effect of oxandrolone and timing of pubertal induction on final height in Turner syndrome: final analysis of the UK randomised placebo-controlled trial. Archives of Disease in Childhood, 106, pp. 74-76. (doi: 10.1136/archdischild-2019-317695) (PMID:31862699)

Abstract

The UK Turner syndrome (TS) study examined the effect on final height of oxandrolone 0.05 mg/kg/day (maximum dose 2.5 mg) versus placebo from 9 years of age; and delaying ethinylestradiol induction of puberty by 2 years from 12 (E12) to 14 (E14) years in growth hormone-treated girls with TS. The study ran from 1999 to 2013. By 2011, eighty-two of 92 participants had reached final height and an interim analysis using the Super-Imposition by Translation And Rotation model showed significant increases in final height with both oxandrolone and E14. The analysis has been repeated now that all 92 patients have reached final height. Oxandrolone still significantly increased final height by 4.1 cm (95% CI 1.6 to 6.6, n=92) compared with 4.6 cm previously. However, the E14 effect was no longer significant at 2.7 cm (95% CI −0.8 to 6.1, n=56) compared with 3.8 cm previously.

• Item Type: Articles
• Additional Information: Funding was provided by the Scottish Executive Chief Scientist Office (1999-2004) (K/MRS/50/C2713) and by the British Society for Paediatric Endocrinology and Diabetes (2004-2013), with a contribution to funding of pharmacy staff from the Child Growth Foundation. Additional funding was received from the NIHR; TJC was funded by Medical Research Council (grant MR/R010692/1).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gault, Miss Emma-Jane
• Authors: Gault, E. J., Cole, T. J., Casey, S., Hindmarsh, P. C., Betts, P., Dunger, D. B., and Donaldson, M. D.C.
• College/School: College of Medical Veterinary and Life Sciences
• Journal Name: Archives of Disease in Childhood
• Publisher: BMJ Group
• ISSN: 0003-9888
• ISSN (Online): 1468-2044
• Published Online: 20 December 2019
• Copyright Holders: Copyright © Author(s) (or their employer(s)) 2019.
• First Published: First published in Archives of Disease in Childhood 106:74-76
• Publisher Policy: Reproduced in accordance with the publisher copyright policy