Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models

Phesse, T. J., Durban, V. M. and Sansom, O. J. (2017) Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models. Carcinogenesis, 38(10), pp. 953-965. (doi: 10.1093/carcin/bgx080) (PMID:28981588) (PMCID:PMC5862284)

Abstract

Over the past 20 years, huge advances have been made in modelling human diseases such as cancer using genetically modified mice. Accurate in vivo models are essential to examine the complex interaction between cancer cells, surrounding stromal cells, tumour-associated inflammatory cells, fibroblast and blood vessels, and to recapitulate all the steps involved in metastasis. Elucidating these interactions in vitro has inherent limitations, and thus animal models are a powerful tool to enable researchers to gain insight into the complex interactions between signalling pathways and different cells types. This review will focus on how advances in in vivo models have shed light on many aspects of cancer biology including the identification of oncogenes, tumour suppressors and stem cells, epigenetics, cell death and context dependent cell signalling.

• Item Type: Articles
• Additional Information: T.J.P. is funded by a Wellcome Trust ISSF Fellowship, and a Capital Medical University/Cardiff University Fellowship. V.M.D. is funded by a European Cancer Stem Cell Research institute fellowship and O.J.S. is funded by a Cancer Research UK programme grant (A21139) and ERC investigator award ‘ColonCan’ (311301).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Sansom, Professor Owen
• Authors: Phesse, T. J., Durban, V. M., and Sansom, O. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Carcinogenesis
• Publisher: Oxford University Press
• ISSN: 0143-3334
• ISSN (Online): 1460-2180
• Published Online: 23 August 2017