Dobson, A. J. , Johnston, P. R., Vilcinskas, A. and Rolff, J. (2012) Identification of immunological expressed sequence tags in the mealworm beetle Tenebrio molitor. Journal of Insect Physiology, 58(12), pp. 1556-1561. (doi: 10.1016/j.jinsphys.2012.09.009) (PMID:23041376)
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Abstract
Understanding the evolutionary ecology of immune responses to persistent infection could provide fundamental insight into temporal dynamics or interactive mechanisms that could be co-opted for antibiotic treatment regimes. Additionally, identification of novel molecules involved in these processes could provide novel compounds for biotechnological development. The beetle Tenebrio molitor displays a high level of induced antimicrobial activity coincident with persistent immuno-resistant Staphylococcus aureus, and is the first invertebrate model for persistent infection. Here we present expressed sequence tags (ESTs) detected by suppression-subtraction hybridization of Tenebrio larvae after infection with S. aureus. Amongst others, we identified mRNAs coding for various oxidative enzymes and two antimicrobial peptides. These ESTs provide a foundation for mechanistic study of Tenebrio's immune system.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Dobson, Dr Adam |
| Authors: | Dobson, A. J., Johnston, P. R., Vilcinskas, A., and Rolff, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Journal of Insect Physiology |
| Publisher: | Elsevier |
| ISSN: | 0022-1910 |
| ISSN (Online): | 1879-1611 |
| Published Online: | 04 October 2012 |
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