Increased survival of experimentally evolved antimicrobial peptide-resistant Staphylococcus aureus in an animal host.

Dobson, A. J. , Purves, J. and Rolff, J. (2014) Increased survival of experimentally evolved antimicrobial peptide-resistant Staphylococcus aureus in an animal host. Evolutionary Applications, 7(8), pp. 905-912. (doi:10.1111/eva.12184) (PMID:25469169) (PMCID:PMC4211720)

[img]
Preview
Text
202540.pdf - Published Version
Available under License Creative Commons Attribution.

277kB

Abstract

Antimicrobial peptides (AMPs) have been proposed as new class of antimicrobial drugs, following the increasing prevalence of bacteria resistant to antibiotics. Synthetic AMPs are functional analogues of highly evolutionarily conserved immune effectors in animals and plants, produced in response to microbial infection. Therefore, the proposed therapeutic use of AMPs bears the risk of ‘arming the enemy’: bacteria that evolve resistance to AMPs may be cross‐resistant to immune effectors (AMPs) in their hosts. We used a panel of populations of Staphylococcus aureus that were experimentally selected for resistance to a suite of individual AMPs and antibiotics to investigate the ‘arming the enemy’ hypothesis. We tested whether the selected strains showed higher survival in an insect model (Tenebrio molitor) and cross‐resistance against other antimicrobials in vitro. A population selected for resistance to the antimicrobial peptide iseganan showed increased in vivo survival, but was not more virulent. We suggest that increased survival of AMP‐resistant bacteria almost certainly poses problems to immune‐compromised hosts.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dobson, Dr Adam
Authors: Dobson, A. J., Purves, J., and Rolff, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Evolutionary Applications
Publisher:Wiley
ISSN:1752-4563
ISSN (Online):1752-4571
Published Online:02 July 2014
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Evolutionary Applications 7(8): 905-912
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record