Mescola, A., Vella, S., Scotto, M., Gavazzo, P., Canale, C., Diaspro, A., Pagano, A. and Vassalli, M. (2012) Probing cytoskeleton organisation of neuroblastoma cells with single-cell force spectroscopy. Journal of Molecular Recognition, 25(5), pp. 270-277. (doi: 10.1002/jmr.2173) (PMID:22528188)
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Abstract
Single‐cell force spectroscopy is an emerging technique in the field of biomedicine because it has proved to be a unique tool to obtain mechanical and functional information on living cells, with force resolution up to single molecular bonds. This technique was applied to the study of the cytoskeleton organisation of neuroblastoma cells, a life‐threatening cancer typically developing during childhood, and the results were interpreted on the basis of reference experiments on human embryonic kidney cell line. An intimate connection emerges among cellular state, cytoskeleton organisation and experimental outcome that can be potentially exploited towards a new method for cancer stadiation of neuroblastoma cells.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Vassalli, Professor Massimo |
Authors: | Mescola, A., Vella, S., Scotto, M., Gavazzo, P., Canale, C., Diaspro, A., Pagano, A., and Vassalli, M. |
College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
Journal Name: | Journal of Molecular Recognition |
Publisher: | Wiley |
ISSN: | 1099-1352 |
ISSN (Online): | 1099-1352 |
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