Establishment of Wolbachia strain wAlbB in Malaysian populations of Aedes aegypti for dengue control

Nazni, W. A. et al. (2019) Establishment of Wolbachia strain wAlbB in Malaysian populations of Aedes aegypti for dengue control. Current Biology, 29(24), 4241-4248.e5. (doi: 10.1016/j.cub.2019.11.007) (PMID:31761702) (PMCID:PMC6926472)

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Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti. The wMel Wolbachia strain has previously been trialed in open releases of Ae. aegypti; however, the wAlbB strain has been shown to maintain higher density than wMel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying wAlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency at some sites or persisted with additional releases following fluctuations at other sites. Based on passive case monitoring, reduced human dengue incidence was observed in the release sites when compared to control sites. The wAlbB strain of Wolbachia provides a promising option as a tool for dengue control, particularly in very hot climates.

Item Type:Articles
Additional Information:The primary funding for the study was provided by Wellcome Trust Award 108508, with additional funding from Wellcome Trust Award 202888 and National Health and Medical Research Council of Australia Awards 1118640 and 1132412 and funding from Ministry of Health Malaysia.
Glasgow Author(s) Enlighten ID:Sinkins, Professor Steven and Ant, Dr Thomas and Herd, Dr Christie and Mancini, Dr Maria Vittoria
Authors: Nazni, W. A., Hoffmann, A. A., NoorAfizah, A., Cheong, Y. L., Mancini, M. V., Golding, N., Kamarul, G. M.R., Arifi, M. A.K., Thohir, H., NurSyamimi, H., ZatilAqmar, M. Z., NurRuqqayah, M., NorSyazwani, A., Faiz, A., Irfan, F.-R. M.N., Rubaaini, S., Nuradila, N., Nizam, N. M.N., Irwan, S. M., Endersby-Harshman, N. M., White, V. L., Ant, T. H., Herd, C. S., Hasnor, A. H., AbuBakar, R., Hapsah, D. M., Khadijah, K., Kamilan, D., Lee, S. C., Paid, Y. M., Fadzilah, K., Topek, O., Gill, B. S., Lee, H. L., and Sinkins, S. P.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Current Biology
Publisher:Elsevier (Cell Press)
ISSN (Online):1879-0445
Published Online:21 November 2019
Copyright Holders:Copyright © 2019 Published by Elsevier Ltd
First Published:First published in Current Biology 29(24):4241-4248.e5
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174018Wolbachia-based control of virus transmission by the mosquito Aedes albopictusSteven SinkinsWellcome Trust (WELLCOTR)108508/Z/15/ZIII-MRC-GU Centre for Virus Research
173477Wolbachia-mediated arbovirus inhibition in mosquitoesSteven SinkinsWellcome Trust (WELLCOTR)202888/Z/16/ZIII-MRC-GU Centre for Virus Research