Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines

Klenke, B., Barrett, M. , Brun, R. and Gilbert, I. (2003) Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines. Journal of Antimicrobial Chemotherapy, 52(2), pp. 290-293. (doi: 10.1093/jac/dkg307)

Abstract

Polyamine biosynthesis and function has been shown to be a good drug target in some parasitic protozoa and it is proposed that the pathway might also represent a target in the malaria parasite Plasmodium falciparum. A series of 1,3,5-triazine-substituted polyamine analogues were tested for activity against Plasmodium falciparum in vitro. The series showed activity against the parasites and were generally more active against the chloroquine-resistant line K1 than the chloroquine-susceptible line NF54. Simple unbranched analogues had better activity than analogues carrying branched or cyclic central chains. Addition of multiple triazine units in general led to increased activity of the compounds

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Barrett, Professor Michael
• Authors: Klenke, B., Barrett, M., Brun, R., and Gilbert, I.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Journal of Antimicrobial Chemotherapy
• Publisher: Oxford University Press
• ISSN: 0305-7453