Local human movement patterns and land use impact exposure to zoonotic malaria in Malaysian Borneo

Fornace, K. M. et al. (2019) Local human movement patterns and land use impact exposure to zoonotic malaria in Malaysian Borneo. eLife, 8, e47602. (doi: 10.7554/elife.47602) (PMID:31638575) (PMCID:PMC6814363)

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Human movement into insect vector and wildlife reservoir habitats determines zoonotic disease risks; however, few data are available to quantify the impact of land use on pathogen transmission. Here, we utilise GPS tracking devices and novel applications of ecological methods to develop fine-scale models of human space use relative to land cover to assess exposure to the zoonotic malaria Plasmodium knowlesi in Malaysian Borneo. Combining data with spatially explicit models of mosquito biting rates, we demonstrate the role of individual heterogeneities in local space use in disease exposure. At a community level, our data indicate that areas close to both secondary forest and houses have the highest probability of human P. knowlesi exposure, providing quantitative evidence for the importance of ecotones. Despite higher biting rates in forests, incorporating human movement and space use into exposure estimates illustrates the importance of intensified interactions between pathogens, insect vectors and people around habitat edges.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Fornace, Dr Kimberly and Ferguson, Professor Heather
Creator Roles:
Ferguson, H.Methodology, Writing – review and editing
Authors: Fornace, K. M., Alexander, N., Abidin, T. R., Brock, P. M., Chua, T. H., Vythilingam, I., Ferguson, H. M., Manin, B. O., Wong, M. L., Ng, S. H., Cox, J., and Drakeley, C.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:eLife
Publisher:eLife Sciences Publications, Ltd
ISSN (Online):2050-084X
Copyright Holders:Copyright © 2019 Fornace et al.
First Published:First published in eLife 8:e47602
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
167761Defining the biomedical, environmental and social risk factors for human infection with Plasmodium knowlesiHeather FergusonMedical Research Council (MRC)G1100796/1Institute of Biodiversity, Animal Health and Comparative Medicine