Pseudokinases: a tribble‐edged sword

Richmond, L. and Keeshan, K. (2020) Pseudokinases: a tribble‐edged sword. FEBS Journal, 287(19), pp. 4170-4182. (doi: 10.1111/febs.15096) (PMID:31621188)

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Advances in the understanding of the Tribbles family of pseudokinases (TRIB1, TRIB2 and TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis, prognosis, prediction and clinical strategy. In their role as signalling mediators and scaffolding proteins, TRIBs lead to changes in protein stability and activity which impact on diverse cellular processes such as proliferation, differentiation, cell cycle and cell death. We review the role of TRIB proteins as promising therapeutic targets, with an emphasis on their role in cancer and as biomarkers with potential application across diverse pathological processes.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Richmond, Dr Laura and Keeshan, Dr Karen
Authors: Richmond, L., and Keeshan, K.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:FEBS Journal
ISSN (Online):1742-4658
Published Online:16 October 2019
Copyright Holders:Copyright © 2019 Federation of European Biochemical Societies
First Published:First published in FEBS Journal 287(19):4170-4182
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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