An audit of the management of elderly patients with glioblastoma in the UK: have recent trial results changed treatment?

Chong, M. Y., Lorimer, C. F., Mehta, S., Ibrahim, E., Brock, J., McBain, C., McLoone, P. and Chalmers, A. J. (2019) An audit of the management of elderly patients with glioblastoma in the UK: have recent trial results changed treatment? CNS Oncology, 8(4), CNS47. (doi: 10.2217/cns-2019-0017) (PMID:31818127) (PMCID:PMC6974914)

Abstract

Aim: We investigated uptake of short-course chemo-radiotherapy and compared outcomes with other treatment schedules in elderly patients with glioblastoma (GBM). Methods: Patients aged 65 or over with a diagnosis of GBM were identified from an 18-month period from three centers in the UK. The primary end point of this study was overall survival from the date of diagnosis. Results: The analysis included 210 patients. Overall median survival was 5.0 months. Approximately 31.9% of patients received combined chemoradiation; multivariate analysis showed that patients who received standard chemoradiation were at a reduced risk of death than those receiving hypofractionated chemoradiation. Discussion: In this retrospective study, patients treated with standard chemoradiation experienced better outcomes than patients receiving hypofractionated chemoradiation. Patient selection likely contributed to these findings.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McLoone, Mr Philip and Chalmers, Professor Anthony
• Authors: Chong, M. Y., Lorimer, C. F., Mehta, S., Ibrahim, E., Brock, J., McBain, C., McLoone, P., and Chalmers, A. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
• Journal Name: CNS Oncology
• Publisher: Future Medicine
• ISSN: 2045-0907
• ISSN (Online): 2045-0915
• Published Online: 10 December 2019
• Copyright Holders: Copyright © 2019 Ming Yao Chong
• First Published: First published in CNS Oncology 8(4):CNS47
• Publisher Policy: Reproduced under a Creative Commons License