Laryngeal cancer risks in workers exposed to lung carcinogens: exposure-effect analyses using a quantitative job exposure matrix.

Hall, A. L. et al. (2020) Laryngeal cancer risks in workers exposed to lung carcinogens: exposure-effect analyses using a quantitative job exposure matrix. Epidemiology, 31(1), pp. 145-154. (doi: 10.1097/EDE.0000000000001120) (PMID:31577634)

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200759.pdf - Accepted Version



Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders. This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the INHANCE Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989-2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI & nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, chromium-VI & nickel) and females (asbestos, respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant. Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, p-values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI & nickel); strongest associations were for asbestos at >90%ile cumulative exposure (OR=1.3, CI=1.0-1.6), respirable crystalline silica at 30+ years duration (OR=1.4, CI=1.2-1.7) and 75%-90%ile cumulative exposure (OR=1.4, CI=1.1-1.8), chromium-VI at >75%ile cumulative exposure (OR=1.9, CI=1.2-3.0), and chromium-VI & nickel at 20-29 years duration (OR=1.5, CI=1.1-2.2). These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.

Item Type:Articles
Additional Information:This work was also supported with the following funding: SYNERGY Project German Social Accident Insurance (DGUV) INHANCE Pooled Data Project National Cancer Institute (NCI) [R03CA113157] National Institute of Dental and Craniofacial Research (NIDCR) [R03DE016611] Western Europe (ARCAGE) study European Community (5th Framework Programme) [QLK1-CT-2001- 00182] Germany-Heidelberg study The German Ministry of Education and Research [01GB9702/3] Latin America study Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina, IMIM (Barcelona), São Paulo Research Foundation (FAPESP) [01/01768-2], and European Commission [IC18-CT97-0222] ICARE study French National Research Agency (ANR); French National Cancer Institute (INCA); French Agency for Food, Environmental and Occupational Health and Safety (ANSES); French Institute for Public Health Surveillance (InVS); Fondation pour la Recherche Médicale (FRM); Fondation de France; Fondation ARC pour la Recherche sur le Cancer; French Ministry of Labour (Direction Générale du Travail); French Ministry of Health (Direction Générale de la Santé).
Glasgow Author(s) Enlighten ID:Conway, Professor David
Authors: Hall, A. L., Kromhout, H., Schüz, J., Peters, S., Portengen, L., Vermeulen, R., Agudo, A., Ahrens, W., Boffetta, P., Brennan, P., Canova, C., Conway, D. I., Curado, M. P., Daudt, A. W., Fernandez, L., Hashibe, M., Healy, C. M., Holcatova, I., Kjaerheim, K., Koifman, R., Lagiou, P., Luce, D., Macfarlane, G. J., Menezes, A., Menvielle, G., Polesel, J., Ramroth, H., Richiardi, L., Stücker, I., Thomson, P., Vilensky, M., Wunsch-Filho, V., Lee, Y.-C. A., Znaor, A., Straif, K., and Olsson, A.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Epidemiology
Publisher:Wolters Kluwer
ISSN (Online):1531-5487
Published Online:01 October 2019
Copyright Holders:Copyright © 2019 Wolters Kluwer
First Published:First published in Epidemiology 31(1):145-154
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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