Trujillo, S. , Pérez-Román, E., Kyritsis, A., Gómez Ribelles, J. L. and Pandis, C. (2015) Organic-inorganic bonding in chitosan-silica hybrid networks: physical properties. Journal of Polymer Science Part B: Polymer Physics, 53(19), pp. 1391-1400. (doi: 10.1002/polb.23774)
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Abstract
Novel biomaterials are needed for bone tissue repair with improved mechanical performance compared to classical bioceramics. The objective of this work was to characterize a hybrid filler material, which is capable to coat as a thin film porous scaffolds improving their mechanical properties for bone tissue engineering. The hybrid filler material is a blend of chitosan and silica network formed through in situ sol–gel using tetraethylortosilicate and 3‐glycidoxypropyltrimethoxysilane (GPTMS) as silica precursors. The hypothesis was that the epoxy ring of GPTMS could react with the amino groups of chitosan in acidic media while it is also reacting the siloxane groups of hydrolyzed silica precursors. The formation of the hybrid organic–inorganic network was assessed by different physical techniques revealing changes in molecular mobility and hydrophilicity upon chemical reaction. Finally, the cytotoxicity of the samples was also evaluated by MTT assay.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Trujillo Munoz, Dr Sara |
| Authors: | Trujillo, S., Pérez-Román, E., Kyritsis, A., Gómez Ribelles, J. L., and Pandis, C. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Journal of Polymer Science Part B: Polymer Physics |
| Publisher: | Wiley |
| ISSN: | 0887-6266 |
| ISSN (Online): | 1099-0488 |
| Published Online: | 25 June 2015 |
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